Genome instability: when RNA meets chromatin

 

REGISTRATION REQUEST and ABSTRACT SUBMISSION DEADLINE:  : May 28, 2019

 

To attend the conferences Jacques Monod, an abstract submission is mandatory,

Registrations request without abstract submission will not be processed, except in specific

cases (i. g. for Publishers : please contact chairperson).

 

Chairperson: Andrés Aguilera

CABIMER-Universidad de Sevilla, Av. Américo Vespucio 24, 41092 Sevilla, Spain 

Phone: +34 954 468 372

Email: aguilo@us.es

 

Vice-chairperson: Gaelle Legube

CBI (Centre de Biologie Integrative) LBCMCP-CNRS UMR5088, University of Toulouse, 118 route de Narbonne, 31062 Toulouse, Cedex 09, France

Phone: +33 (0)5 61 55 74 97

Email: gaelle.legube@univ-tlse3.fr

 

Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.

 

Applications submission

Registration fee (including board and lodging)

500 € for PhD students
700 € for other participants

 

Application for registration   details here :
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should deposit on line :

- their curriculum vitae
- the proof of their student status
- the list of their main publications for the 3 last years
- the abstract of their presentation:

The abstract must respect the following template: TemplateResumeFile
- First line: title
- Second line: list of authors. Presenting author underlined
- Third line: author's addresses
- Fourth line: e-mail of the presenting author
Abstracts should be no longer than an A4 page and preferably be submitted in Times New Roman, font size 10 pts. No figures. ".docx" file format.

After deadline, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.

 

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